It has been found that the prevalence of enamel defect in children with Celiac disease was significantly higher than their peers. These defects are mainly characterized by pitting, grooving and sometimes by complete loss of enamel. The most affected teeth are incisors and molars. When the possible causes for the changes in the enamel were investigated it has been found enamel mineralization disturbances did not occur before the children started eating gluten. This may point to a possible explanation for the enamel defects. This correlation between gluten in the diet and enamel defects in was found in studies from many countries. The possible explanation could be hypocalcemia or, more likely, a particular genetic condition that leads to a specific immune response to gluten.